Reply: Methylphenidate and the Cytochrome P450 System

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Methylphenidate and the cytochrome P450 system.

Mrs WP, aged 69 years, was admitted to the psychiatric unit of our hospital with symptoms consistent with acute mania. She exhibit grandiose ideation, euphoria, psychomotor excitement, flight of ideas, and pressure of speech. She also exhibited overt sexual acts, such as running nude in the unit. This patient has a long history of bipolar affective disorder type 1, and she has been followed up ...

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Inactivation of the hepatic cytochrome P450 system by conditional deletion of hepatic cytochrome P450 reductase.

Cytochrome P450 (CYP) monooxygenases catalyze the oxidation of a large number of endogenous compounds and the majority of ingested environmental chemicals, leading to their elimination and often to their metabolic activation to toxic products. This enzyme system therefore provides our primary defense against xenobiotics and is a major determinant in the therapeutic efficacy of pharmacological a...

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Cytochrome P450 monooxygenase system in echinoderms.

The results of a limited number of studies on echinoderms provide evidence for the presence of a cytochrome P450 monooxygenase system in representatives of three classes of the phylum Echinodermata: the asteroids (sea stars), holothuroids (sea cucumbers) and echinoids (sea urchins). The monooxygenase system has been demonstrated to be involved in the metabolism of xenobiotic compounds, but is a...

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Some fruit juices and fruits can interact with numerous drugs, in many cases causing adverse. These chemicals inhibit key drug metabolizing enzymes, such as cytochrome P450 3A4 (CYP3A4).. .. Covera HS, Isoptin SR, Verelan); Warfarin (coumadin); Zolpidem (Ambien): Little or no interaction with grapefruit juice. The aim of this study was to identify the form(s) of cytochrome P450 (CYP) responsibl...

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ژورنال

عنوان ژورنال: The Canadian Journal of Psychiatry

سال: 2003

ISSN: 0706-7437,1497-0015

DOI: 10.1177/070674370304800616